C Reactive Protein (also known as C-RP; PTX1; Pentraxin-Related; Pentraxin 1) is a protein involved in the activation, amplification, and regulation of the complement system.2 CRP is often also involved in defense related functions including identifying foreign pathogens and removal of damaged host cells.2 As a result, levels of CRP are often elevated at the onset of infection, or immediately after tissue injury.2 High levels of CRP have also been found in patients infected with COVID-19.3

 

Recent studies have looked at a variety of different biomarkers in relation to COVID-19, and several laboratory abnormalities associated with poor prognosis with COVID-19.4 Among these, the concentration of CRP in patients has been shown to be an important marker for infection outcome.5 Patients who die from a COVID-19 infection have been seen to maintain a high level of CRP.5 As a result, CRP is a possible predictor of prognosis for COVID-19 infection and can be a test for quickly identifying patients who may need enhanced monitoring for respiratory distress or dysfunction to avoid the worsening of their condition.6

 

Reddot Biotech is pleased to offer a Human C Reactive Protein ELISA kit in both our traditional and Ready-To-Use formats. Our Human CRP kits have a nanogram range (detection range 0.156-10ng/mL; sensitivity 0.057ng/mL) and are suitable for use with a wide variety of different sample types. For more information and to see the product manual, visit our product pages for RDR-CRP-Hu and RD-CRP-Hu. For any other questions, please feel free to contact us.

 

References and further reading:

  1. CRP C-reactive protein [Homo sapiens (human)] - Gene - NCBI. (n.d.). Retrieved September 18, 2020, from https://www.ncbi.nlm.nih.gov/gene/1401
  2. McFadyen, J. D., Zeller, J., Potempa, L. A., Pietersz, G. A., Eisenhardt, S. U., & Peter, K. (2020). C-Reactive Protein and Its Structural Isoforms: An Evolutionary Conserved Marker and Central Player in Inflammatory Diseases and Beyond. In Vertebrate and Invertebrate Respiratory Proteins, Lipoproteins and other Body Fluid Proteins (pp. 499-520). Springer, Cham.
  3. Gao, M., Wang, Q., Wei, J., Zhu, Z., & Li, H. Severe Coronavirus disease 2019 pneumonia patients showed signs of aggravated renal impairment. Journal of Clinical Laboratory Analysis, e23535.
  4. Lippi, G., & Plebani, M. (2020). Laboratory abnormalities in patients with COVID-2019 infection. Clinical Chemistry and Laboratory Medicine (CCLM)58(7), 1131-1134.
  5. Sahu, B. R., Kampa, R. K., Padhi, A., & Panda, A. K. (2020). C-reactive protein: a promising biomarker for poor prognosis in COVID-19 infection. Clinica Chimica Acta.
  6. Erika, P., Domenica, Z., Paolo, I., Luca, R., Giulia, L., Alessandro, D., ... & Andrea, M. (2020). Lactate dehydrogenase and C-reactive protein as predictors of respiratory failure in CoVID-19 patients. Clinica Chimica Acta.

 

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